Twenty-five patients were also treated by immunosuppressive treatments including Tumor Necrosis Factor alpha agonists (anti-TNFα): 11 patients had hydroxychloroquine, methotrexate, azathioprine as a corticosteroid-sparing treatment; nine patients had methotrexate, azathioprine, mycophenolate mofetil, or cyclophosphamide for uncontrolled sarcoidosis under corticosteroid therapy, five patients required anti-TNFα because of relapse despite a second-line treatment. This evidence concerns the gene TNF and sarcoidosis.