CD274 and non-small cell lung carcinoma: Interestingly, an additional study assessing pembrolizumab efficacy versus chemotherapy using a PD-L1 tumor proportion score (TPS) of 1% or greater (KEYNOTE-042 [13]) demonstrated improved OS for the full cohort, which, despite being higher for higher PD-L1 expression, supported a potential extended role of pembrolizumab monotherapy as a standard first-line treatment for PD-L1-expressing advanced/metastatic NSCLC [14].