We performed a systematic literature review from PubMed with significant keywords including COVID-19 and ACE2 (675 hits), COVID-19 and RAAS (52 hits), COVID-19 and ACE inhibitors (223 hits), COVID-19 and ARBs (71 hits), COVID-19 and mineralocorticoid inhibitors (6 hits), ACE2 and ACE inhibitors (1073 hits), ACE2 and ARBs (55 hits), ADAM17 and ACE2 (43 hits). The gene discussed is ADAM17; the disease is COVID-19.