NT5E and neoplasm: Moreover, since focal radiotherapy induces overexpression of CD73 and, thus, an increment in ADO in the TME, blocking of CD73 has been assayed in combination with focal radiotherapy and immune checkpoint blockade (directed to cytotoxic T-lymphocyte-associated protein 4, PDL-1 and PD-1 in breast cancer cells); in these assays, CD73 blocks improved DC infiltration and the induction of anti-tumor T cell-dependent responses [167].