Accordingly, it has been demonstrated that UTP activation of P2Y2R induced proliferation in C6 glioma cells [50], in human cutaneous squamous cell carcinoma lines (A431) [47]; in pancreatic duct epithelial cells PANC-1 [51]; in hepatocarcinoma cell lines HepG2 and Bell-7404 [49]; and in the gastric cancer lines AGS and MKN-74 [52]. This evidence concerns the gene P2RY2 and central nervous system cancer.