ATP release by cancer cells and the subsequent activation of purinergic receptors and intracellular pathways have been reported in various cancer models, such as pheochromocytoma PC-12 cells stimulated with maitotoxin [13]; Ehrlich ascites tumor cells, ATP release induced by mechanical stimulation [14]; A549 human lung cancer cells, by exocytosis triggered by TGF-β stimulation [15]; SKOV-3 ovarian carcinoma-derived cells released by a pipette generated flux [16]; I-10 testicular cancer cells through pannexin-1 [17]. This evidence concerns the gene P2RX4 and cancer.