Finally, CMRF35-like molecule 1, encoded by CD300LF, acts as an inhibitory receptor in myeloid cells and mast cells [33], with anti-human CMRF35-like molecule 1 antibodies displaying complement- and antibody-dependent cell cytotoxicity against CMRF35-like molecule 1-expressing AML-derived cell lines and freshly isolated blasts from AML patients in vitro [34]. Here, CD300LF is linked to acute myeloid leukemia.