Several immune-biomarkers have been highlighted as useful prognostic indicators for HNSCC [10,11,12,13]; for instance, circulating CD8+ T cell levels prior to treatment have been found to be associated with improved survival in patients with advanced oropharyngeal cancer [10], while high tumor-infiltrating lymphocyte levels are related with increased overall survival (OS) [11], and increased CD68+ macrophage counts in oral squamous cell carcinoma are known to be significantly correlated with mortality [12]. This evidence concerns the gene CD8A and neoplasm.