Notably, as early as 2008, Kistorp et al. [74] described elevated circulating biomarkers of endothelial dysfunction (von Willebrand factor and E-selectin) and their relation to prognosis in HF patients with DM in contrast to nondiabetic HF subjects; however, they studied only patients with EF ≤ 45%. This evidence concerns the gene SELE and hydrops fetalis.