TYK2 and type 1 diabetes mellitus: However, single nucleotide polymorphisms (SNPs) in immune response genes such as DDX58 (DExD/H-Box Helicase 58), TLR2 (Toll-like receptor 2), TLR3 (Toll-like receptor 3), TLR7 (Toll-like receptor 7), TYK2 (tyrosine kinase 2), and IFIH1 (Interferon Induced With Helicase C Domain 1) are implicated with T1D disease risk [13,14,15,16,17,18,19,20,21,22,23,24,25].