TTK and Mental deterioration: Interestingly, when looking at the initial reasons for hospitalization (epileptic seizures, focal neurological symptoms, cognitive decline and/or general symptoms, or incidental finding), GBM patients with MPS1 expression above this threshold more often had focal neurological symptoms or epileptic seizures (11 of 14, 79%), compared to those with MPS1 expression below the median (8 of 13, 62%) (Figure 2a).