TTK and glioblastoma: When we analyzed the different GBM-subgroups distinguished by their growth pattern (primary local tumors leading to local relapse, primary local tumors leading to multifocal relapse and primary multifocal tumors) and compared primary tumors and relapses, we did not observe any statistically significant difference in MPS1 mRNA expression (p > 0.05) (Figure 1c and Table 3).