However, a pathophysiological function has also be assigned to ACE2, which is as the entry receptor for SARS-Cov-1 and the novel SARS-Cov-2 viruses, which have been responsible for the sever acute respiratory syndrome (SARS) epidemic in 2003 and the current coronavirus infectious disease (COVID-19) pandemic, respectively [1]. The gene discussed is ACE2; the disease is severe acute respiratory syndrome.