BCL2L11 and breast neoplasm: On the other hand, the splicing factor SRSF1 has been observed to be upregulated in breast tumors acting as an oncogene by producing impaired splicing isoforms of the pro-apoptotic genes BCL2 Like 11 (BIM) and the Bridging integrator 1 (BIN1) which are involved in the tumoral phenotype.