ARHGEF10 and neoplasm: With respect to the top tumor driver genes that were more regulated by OncoMMRs, these were the tumor suppressor genes FAT homolog 4 (FAT4), Kruppel like factor 6 (KLF6), Rho guanine nucleotide exchange factor 10 (ARHGEF10), and the RB transcriptional corepressor 1 (RB1); all of them were downregulated in tumoral tissues.