ARHGEF10 and breast carcinoma: Moreover, we found that the tumor suppressor ARHGEF10 and the oncogene SRFS1 were negatively and positively co-regulated by miR-106b-5p, miR-106a-5p, miR-671-5p, and miR-590-3p, whereas this pattern was observed at the protein level in breast cancer tissues (Figure 7), validating our results.