Studies have also shown that the activation of TLR3 in HSCs by exosomes derived from damaged hepatocytes exacerbates liver fibrosis by enhancing the production of chemokine (C-C motif) ligand 20 (CCL20), interleukin-17A (IL-17A), and exosomal miR-192, which significantly increases the expression of profibrotic markers in HSCs [86]. Here, IL17A is linked to Hepatic fibrosis.