FOXF1, a member of the fork-head family of transcription factors, is specifically expressed in GIST and directly regulates the transcription of KIT and ETV1. In turn, FOXF1 and ETV1 both regulate KIT, although FOXF1 regulation of KIT is significantly stronger owing to the regulation of both chromatin accessibility and the ETV1 cistrome [40]. The gene discussed is ETV1; the disease is gastrointestinal stromal tumor.