For example, in renal cell carcinoma, HOTTIP inhibited autophagy by activating the PI3K/Akt/Atg13 pathway [30], in colon cancer cells, HOTTIP targeted the expression of tumor suppressor DKK1 [31], and in breast cancer, HOTTIP up‐regulated HOXA11 to promote malignant growth [32]. This evidence concerns the gene AKT1 and hereditary clear cell renal cell carcinoma.