Abnormalities in mineral metabolism in CKD include the development hyperphosphataemia, elevations in the phosphatonins fibroblast growth factor (FGF)-23 and parathyroid hormone (PTH), reduced circulating active 1,25-dihydroxyvitamin D and hypo- or hypercalcaemia [1]. The gene discussed is FGF23; the disease is Hypercalcemia.