It has been previously reported that ARRDC3 is associated with many diseases by acting on GPCRs — for instance, ARRDC3 can prevent energy expenditure and promote obesity through inhibiting β2-adrenergic receptor in male mice (22), and ARRDC3 also can suppress breast cancer and prostate cancer progression by regulating GPCR sorting or integrin β4 degradation (17, 23, 24). The gene discussed is ARRDC3; the disease is obesity due to melanocortin 4 receptor deficiency.