CAV1 and neoplasm: We observed positive feedback in Cav‐1‐ROS signalling in PSCs, which facilitated PSC activation and thus promoted metabolic coupling between tumour cells and PSCs, with PSCs tending to undergo glycolysis, resulting in high levels of glycolysis products such as lactate, which are secreted into the intercellular space and absorbed by adjacent tumour cells, which tend to undergo OXPHOS.