CAV1 and neoplasm: In summary, this study shows that positive feedback in Cav‐1‐ROS signalling in PSCs promotes PDAC growth and induces stoma‐tumour cell metabolic coupling in PDAC, with PSCs tending to undergo glycolysis, resulting in high levels of glycolysis products such as lactate, which are secreted into the intercellular space and absorbed by adjacent tumour cells, which tend to undergo OXPHOS.