High concentrations of plasma IFN-γ, IL-1β, IL-6, IL-8, IL-12, IP-10, MCP-1, CXCL8, CXCL10, and CCL2 granules are a result of hyperactivated inflammatory signaling cascades and cytokine storm and are associated with the immunopathological changes and severity of SARS-CoV infection [59]. The gene discussed is CXCL8; the disease is severe acute respiratory syndrome.