Our results revealed that KRT80, AJUBA, S100A11, TMEM9, SLC39A10, FOXQ1, and CLDN1 were upregulated whereas the expressions of SPIB, KRT24, PHLPP2, PLP1, BEST4, ZZEF1, CCDC68, CA7, and C11orf86 were downregulated in colon cancer. Here, CLDN1 is linked to colonic neoplasm.