The TCGA results indicated that SPIB, KRT24, PHLPP2, PLP1, BEST4, CA7, and C11orf86 were all downregulated, while KRT80, SLC39A10, AJUBA, FOXQ1, and CLDN1 exhibited upregulated levels in colon cancer (Supplementary Figure 1). Here, KRT80 is linked to malignant colon neoplasm.