Considering the facts that both PHLPP2 and three lncRNAs are targets of miR-141/miR-424, we come to a consensus thatLINC00402, LINC00461, and SFTA1P possess the ability to act as ceRNAs and improve the expression of PHLPP2 through ceRNA mechanism by binding to miR-141 or miR-424, which ultimately lead to the suppression of pathogenesis in colon cancer (Figure 13). This evidence concerns the gene PHLPP2 and malignant colon neoplasm.