Our results revealed that KRT80, AJUBA, S100A11, TMEM9, SLC39A10, FOXQ1, and CLDN1 were upregulated whereas the expressions of SPIB, KRT24, PHLPP2, PLP1, BEST4, ZZEF1, CCDC68, CA7, and C11orf86 were downregulated in colon cancer. Here, SLC39A10 is linked to malignant colon neoplasm.