Ma et al. reported that SNHG15 induced the cell proliferation and tumorigenesis of pancreatic cancer cells by negatively regulating p15 and krueppel-like factor 2 (KLF2) expression, and the up-regulated expression of p15 and KLF2 could partly reversed the cancer-promoting effect of SNHG15 [17]. Here, KLF2 is linked to familial pancreatic carcinoma.