Du et al. suggested that in renal cell carcinoma cells, SNHG15 could activate the NF-κB signaling pathway and induce epithelial–mesenchymal transformation (EMT) through up-regulating the level of Vimentin and N-cadherin expression and down-regulating the level of E-cadherin, promoting the proliferation, migration and invasion of cancer cells [26]. This evidence concerns the gene NFKB1 and hereditary clear cell renal cell carcinoma.