These data suggested that at matched effector-to-target ratios, PD-L1 CAR haNKs kill multiple human HNSCC targets to a greater degree than haNKs, and that susceptibility to PD-L1 CAR haNK killing can be increased with greater PD-L1 expression following IFNγ pre-treatment of target cells. The gene discussed is IFNG; the disease is head and neck squamous cell carcinoma.