Cumulatively, these data demonstrated that PD-L1 CAR haNKs can also mediate PD-L1-dependent tumor growth inhibition in immunodeficient mice bearing human HNSCCs, possibly through the ability of PD-L1 CAR haNKs to induce IFNγ-dependent PD-L1 expression on tumor cells. This evidence concerns the gene CD274 and neoplasm.