In colon cancer cell lines, overexpression of AKR1B1 has been described in the metastatic SW620 cell line compared to non‐metastatic SW480 cells 29 and several studies have highlighted a lower expression of AKR1B1 in SW480 and HT29.17, 31, 32. Here, AKR1B1 is linked to malignant colon neoplasm.