inactivated Akt and inhibitory kappa B kinase (IKK)inhibited PI3K/Akt and NF‐κB pathwayssuppressed hamster buccal pouch (HBP) carcinomas progressioninhibited mir‐21 vascular endothelial growth factor and hypoxia inducible factor‐1 alpha (HIF‐1α). Here, HIF1A is linked to carcinoma.