TFAM and neoplasm: increased the cells responsiveness to oxidative stressdecreased mitochondrial DNA damagesuppressed tumour cellsincreased Nrf2 (synergy with EGF)increased the Nrf‐2 DNA binding activityand decreased Keap‐1 expressionenhanced the activity of Nrf2 stimulated by EGF in vitro & in vivo, thus, helped the cells adapt to oxidative stressenhanced the mitochondrial biogenesis under oxidative stressPCG‐1α, Nrf1 and TFAM were up‐regulated