A study by Ellis et al.,6 which is one of the biggest studies associated with regional lymph node involvement in Xp11.2 translocation RCC, reported that regional lymph node metastasis was observed in 24/32 (75%) of the ASPSCR1-TFE3 carcinomas and in 5/14 (35.7%) of the PRCC-TFE3 carcinomas. The gene discussed is TFE3; the disease is carcinoma.