Neuroendocrine neoplasms (NENs) are composed a group of tumors exhibiting neuroendocrine phonotypes and are divided into three main categories according to the 2010 World Health Organization classification system: well-differentiated neuroendocrine tumors (NETs); grade 1 and 2, Ki-67 ≤ 20% and/or mitotic count ≤ 20 per 10 high-power fields, poorly differentiated NECs; and grade 3, Ki-67 > 20% and/or mitotic count > 20 per 10 high-power fields and MANECs [11]. The gene discussed is MKI67; the disease is neuroendocrine neoplasm.