Importantly, HDACis exert anti-tumor effects through varieties of pathways, including inducing cell cycle arrest (p21, cyclins) and cell apoptosis, regulating cell autophagy, inhibiting tumor angiogenesis (HIF-1a, VEGF), as well as regulating immune response (antigen presentation, T cell activation and Tregs differentiation) [3–8]. Here, VEGFA is linked to neoplasm.