GSK3B and Behcet disease: To better inform lithium safety, a pharmacogenetic study of urinary concentration phenotypes were assessed in a group of 78 BD patients receiving lithium for a mean of 16 ± 9 years; in association with the GSK3B-50 C/T polymorphism, the authors found a statistically significant, though very modest association, not subjected to multiple testing correction, between the C-allele and kidney function, encouraging larger studies to better ascertain the potential role of GSK3B in informing lithium renal toxicity (Rybakowski et al. 2013).