Induced pluripotent stem cell lines have revealed hyperexcitability phenotypes in BD neurons that are reversed in lithium response patients (Mertens et al. 2015), underscored the importance of GSK3-β and other Wnt signaling members in the BD neuronal cell-lines (Madison et al. 2015), and elicited a promising new “pathway of lithium response”, that governs the phosphorylation of CRMP2, which seems to be indirectly modulating GSK3-β (Tobe et al. 2017). This evidence concerns the gene DPYSL2 and Behcet disease.