Man found that adenovirus replication in tracheal epithelial cells increased significantly after the use of calcitonin antibodies (Man et al. 2015) and Chan et al. found that when H. pylori was infected, e-cadherin would undergo significant methylation and lead to the expansion of the infection range (Chan et al. 2006).These suggest that the pathogen infection will affect the host’s e-cadherin and cause damage to the body. This evidence concerns the gene CALCA and infection.