APOE and Alzheimer disease: Age-related changes in miR-195 expression and synj1 mRNA levels have also been noted in ApoE KI and EFAD mouse brains, with differential expression between ApoE4+/+ and ApoE4−/− mice more prominent at 12 months of age compared to a younger age, whereas differences in miR-195 in EFAD mice are already evident at 4 months of age (data not shown), suggesting that ApoE-genotype associated miR-195 changes might be exacerbated by aging and/or manifestations of AD pathologies.