We next investigated if manipulating miR-195 levels could ameliorate AD-related pathologies using human induced pluripotent stem cells (hiPSCs)-derived neuron and astrocyte co-culture from ApoE4+/+ AD subjects and ApoE3+/+ normal aging subjects (TCW et al., bioRxiv; 10.1101/713362). Here, APOE is linked to Alzheimer disease.