Moreover, no significant differences were seen in miR-195 or miR-374 levels between ApoE4+/− and ApoE4−/− subjects of normal aging or advanced AD either (CDR 0 or 3 and above; data not shown), suggesting the functional involvement of miR-195 in early disease development and acceleration by ApoE4 genotype. Here, APOE is linked to Alzheimer disease.