APOE and Cognitive impairment: Consistently, our data indicate that restoring miR-195 levels in vivo rescues ApoE4-associated cognitive deficits (Fig. 4a, c), ameliorates amyloid plaque burden (Fig. 4e, f) and pTau levels (Fig. 4b, d), and improves lysosomal defects in cultured human iPSC-derived brain cells (Fig. 5).