Thus, IQGAP1 has been implicated in varied virus pathogenesis, including HIV, Ebola and Marburg virus.35–37 In the present study, we reported that IQGAP1 levels were upregulated in HBV-positive HCC tissues compared with HBV-negative HCC tissues, and higher expression of IQGAP1 was associated with poor prognosis of HBV-associated HCC patients. The gene discussed is IQGAP1; the disease is hepatocellular carcinoma.