The A/T/N biomarker framework promulgated by the National Institute on Aging-Alzheimer’s Association was created to be an unbiased classification scheme for the three arms of biomarkers known to underlie AD pathology, namely neuropathological loads of Aβ (A) and tau (T), and neurodegeneration (N, including hypometabolism and brain atrophy)8,9. This evidence concerns the gene MAPT and Alzheimer disease.