Therefore, the candidate miRNAs of NRF2 and their correlations to NRF2 in cancers were predicted and analyzed by Starbase 2.0, miR-450b-5p was selected for experimental validation owing to its tumor-suppressive function and significantly negative association with NRF2 in head and neck squamous cell carcinoma (data was not shown). The gene discussed is NFE2L2; the disease is head and neck squamous cell carcinoma.