To explore the role of NRF2 in RKIP-associated radioresistance regulation in NPC, we successfully knocked down the expression of NRF2 in CNE2 shRKIP cells and overexpressed NRF2 in CNE2-IR RKIP cells by infected cells with respective lentivirus (Fig. 1c). This evidence concerns the gene PEBP1 and nasopharyngeal carcinoma.