Therefore, to reveal the relation between RKIP and NRF2 in NPC radioresistance, in this study, we explored the effects of RKIP alteration on NRF2, detected the role of NRF2 in RKIP-regulating radioresistance, and investigated the regulatory mechanisms of NRF2 by RKIP in NPC. The gene discussed is PEBP1; the disease is nasopharyngeal carcinoma.