The results turn out that miR-450b-5p, which is downregulated and positively regulated by RKIP in radioresistant NPC tissues and cells, could directly target NRF2 and sensitize NPC cells to radiation, which not only identifies a new negative regulator of NRF2, but also presents another case for fulfilling regulatory roles of RKIP via miRNAs. Here, NFE2L2 is linked to nasopharyngeal carcinoma.