The second case was also assigned a lower grade by SKIE, but in this instance SKIE counted a lower number of Ki-67-positive tumor cells (30 versus 40) but a higher number of total tumor cells (1,320 versus 992), resulting in a Ki-67 index of 2.3% (G1) for SKIE and 4.03% (G2) for the pathologist. The gene discussed is MKI67; the disease is neoplasm.