The ErbB-PI3K-Akt signaling axis is the most prominently altered pathway in human breast cancers37, yet despite the established hierarchical signaling relationship between ErbBs, PI3K, and Akt, it remains poorly understood how these mutations confer mammary epithelia with invasive potential35,36 or how they might elicit changes in the surrounding tissue microenvironment, including tortuous, angiogenic, and highly permeable tumor vasculature38,39. Here, PIK3CA is linked to neoplasm.