CD274 and lung adenocarcinoma: Finally, we analyzed the expression of PD-L1 and WIP in human lung adenocarcinoma patients and mouse xenografts, we found that PD-L1 was mainly expressed in cytoplasm in 92 human lung adenocarcinoma tissues, which was not consistent with results of lung adenocarcinoma tissues that PD-L1 expressed in both membrane and cytoplasm49.