CD274 and non-small cell lung carcinoma: We next analyzed the effect of PD-L1 on NSCLC cell migration and invasion, and showed that knockdown of PD-L1 by siRNAs significantly inhibited cell migration and invasion compared with the siRNA control in H460 and H358 cells (Fig. 2a, c), whereas overexpression of PD-L1 promoted cell migration and invasion (Fig. 2b, d).