SGCB and autosomal dominant cerebellar ataxia: As the consumption of NO after acute hemolytic processes leads to rapid inflammatory responses that result in substantial leukocyte recruitment to the blood vessel wall (Almeida et al., 2015), stimulation of sGC (the enzyme target of NO) and intracellular cGMP elevation could represent an approach to reducing inflammation, leukocyte recruitment, and consequent vaso-occlusive processes in SCA.