Furthermore, in vivo, the concomitant administration of hydroxyurea to SCD mice amplified the effects of both BAY 60-2770 and BAY 41-2272 on leukocyte recruitment in the microvasculature, further inhibiting leukocyte adhesion to blood vessel walls when used in combination with a sGC activator/stimulator. This evidence concerns the gene SGCB and Schnyder corneal dystrophy.