As stimulation of cGMP-dependent signaling may have beneficial consequences on leukocyte function (Almeida et al., 2012; Conran and Torres, 2019) in SCA, we investigated the effects of the sGC activator and sGC stimulator, BAY 60-2770 and BAY 41-2272, respectively, on the ex vivo adhesive properties of neutrophils from patients with SCA. The gene discussed is SGCB; the disease is autosomal dominant cerebellar ataxia.