Neutrophils from individuals with SCA generally demonstrate augmented adhesive properties compared with neutrophils from healthy individuals, and this adhesion is further augmented by cellular activation by the inflammatory molecules TNF cytokine and hemin, both of which are elevated in the circulation of individuals with SCA (Lanaro et al., 2009; Schaer et al., 2013). The gene discussed is TNF; the disease is autosomal dominant cerebellar ataxia.