In support of this role, DLG5 may create a scaffold between vinexin-vinculin and β-catenin at cell-cell junctions.24 Cell-cell junction maintenance is crucial for cell polarity.57 Dysfunctional cell polarity has previously been identified as a mechanism for podocyte dysfunction and subsequent nephrotic syndrome pathogenesis.58 Here, DLG5 is linked to nephrotic syndrome.