TRA2B and rheumatoid arthritis: In linear modeling including Bonferroni-Holm correction for multiple testing, only citrullinated TRA2B (cTRA2B) antibodies remained a significant predictor of RA diagnosis (OR 5.3 × 103, 95% CI 0.8 × 103–3.0 × 106, p = 0.047) at optimal sensitivity and specificity of 51.0% and 82.9% (Table 2).