Our findings on TIMP3 expression are in line with previous publications that reported that TIMP3 expression was more pronounced in CAA patients compared to controls, that TIMP3 colocalized with Aβ in leptomeningeal cerebrovascular arteries [24], and that TIMP3 protein levels were increased in brains of AD patients and a mouse model of AD [16]. Here, TIMP3 is linked to Alzheimer disease.