ERBB2 and gallbladder cancer: The therapeutic efficacy of anti-ERBB2 agents on ERBB2-amplified ICCs has not been previously reported, but phase II trials in China and South Korea are set to evaluate the combination of gemcitabine-based chemotherapy with trastuzumab in cases of ERBB2-amplified extrahepatic cholangiocarcinoma and gallbladder cancer (NCT02836847) and BTC (NCT03613168).