This study showed that metformin significantly reduced the tumor xenograft size in the treatment groups, compared with the model group, suggesting that metformin inhibited PI3K/Akt signaling, upregulated p53 signaling, activated MICA protein expression in the tumor cells and inhibited the growth of cervical cancer xenografts in the BALB/c nude mouse model. This evidence concerns the gene TP53 and cervical cancer.