Assessment of PI3K (p110), p-PI3K p85 (Tyr199), Akt, p-Akt (ser473), MICA, HSP70 and p53 expression in the tumor xenografts showed that xenografts of the 250 mg/kg/d metformin treatment group had significantly lower p-PI3K p85 (Tyr199) and p-Akt (ser473) levels, whereas the MICA, HSP70, and p53 expression in the xenografts of the 250 mg/kg/d metformin treatment group was significantly higher, compared to the model group. Here, TP53 is linked to neoplasm.