NR2F2 and metastatic malignant neoplasm in the lymph nodes: Similarly, low NR2F2 transcription levels correlated with increased grade and lymph node metastasis based on the study of GEO and TCGA database [22] suggesting that high NR2F2 transcription levels are associated with favorable clinic outcomes through suppression of transforming growth factor - β (TGF-β) induced EMT.