PKM2 can also be regulated by miRNAs and Lnc-RNAs, for example, miR-122 is down-regulated in HCC tissues, therefore, overexpression of miR-122 in HCC cells can inhibit the expression of PKM2 to promote apoptosis and inhibit migration and invasion of Hep3B cells [161]. Here, PKM is linked to hepatocellular carcinoma.