Lin et al. used a small molecule inhibitor of c-Myc, which was 10,058-F4, to treat HCC cell lines, and the results showed that this molecule could inhibit the proliferation and enhance chemosensitivity of HCC cells to low-dose doxorubicin, 5-fluorouracil and cisplatin [145]. The gene discussed is MYC; the disease is hepatocellular carcinoma.