AKT1 and hepatocellular carcinoma: For example, miR-342-3p, miR-455-5p and miR-505 are all down-regulated in HCC tissues, and they have been reported to be able to decrease glycolysis by inhibiting GLUT1 expression through insulin growth factor receptor 1 (IGF-1R) or the PI3K/AKT pathway [148–150].