NOTCH4 and age-related macular degeneration: We identified eight statistical driver genes (SDGs) that were significantly contributing to the significant AMD-associated pathways from PARIS: C2, C3, LIPC, MICA, NOTCH4, PLCG2, PPARA, and RAD51B. Of these eight SDGs, two genes (PLCG2 and PPARA) fell outside of the 34 AMD susceptibility loci identified by the IAMDGC GWAS [8]; we showed that these loci may be associated with ADV risk [14].