This included common variants from the 8 SDGs that exhibited significant signals across significant pathways (p < 0.0001) from KEGG, Reactome, and GO pathway databases and the 2 SDGs (PPARA and PLCG2) that fell outside of the known AMD loci identified by the IAMDGC in their recent GWAS. This evidence concerns the gene PLCG2 and age-related macular degeneration.