Besides, protein kinase, DNA-activated, catalytic subunit (PRKDC), which is an important DNA-dependent protein kinase catalytic subunit, has been reported the over-expression in multiple human RCC tissues, and its inhibition via pharmacological inhibitors or siRNA/shRNA knockdown can significantly reduce the RCC cell proliferation in vitro and in vivo [24]. The gene discussed is PRKDC; the disease is renal cell carcinoma.