CD4 and progressive multifocal leukoencephalopathy: With 78% of the 37.9 million people living with HIV/AIDS in 2018 living in high-burden, limited-resource countries in Africa and South-East Asia [88], new cases of PML will continue to emerge, as these patients tend to present late in the course of HIV disease, in profoundly immunosuppressed clinical condition, with low CD4+ counts and high viral loads [89].