Furthermore, based on multivariate Cox’s regression analysis, we found that tumor CCT6A high expression (P < 0.001, HR 1.779 (95%CI 1.378–2.298)) was an independent predictive factor for predicting poor OS, and poor differentiation (P = 0.003, HR 1.360 (95%CI 1.113–1.663)), LYN metastasis (P < 0.001, HR 2.825 (95%CI 2.183–3.656)) as well as abnormal CEA (>5.0 ng/mL) (P < 0.001, HR 1.816 (95%CI 1.393–2.368)) independently predicted shorter OS in NSCLC patients as well. Here, CCT6A is linked to neoplasm.