SREBF1 and steatosis: In a further stage, the progression to steatosis involves the activation of various transcription factors such as sterol regulatory element binding protein 1c (SREBP-1c), peroxisome proliferator-activated receptor γ (PPARγ) and carbohydrate responsive element-binding protein (ChREBP), which activate the expression of a series of genes essential for lipogenesis [64].