Forward stepwise multivariate Cox’s regression further disclosed that katanin P60-high expression (P = 0.002, HR = 1.527), LYN metastasis (P < 0.001, HR = 2.395), and abnormal CEA level (P = 0.020, HR = 1.382) were independent predictive factors for poor DFS in NSCLC patients. The gene discussed is CEACAM5; the disease is non-small cell lung carcinoma.