For further validation, katanin P60 mRNA expression was detected in 40 fresh tumor samples (Supplementary Figure 1A); then, katanin P60 mRNA high expression was also shown to be correlated with LYN metastasis (P = 0.038) and higher TNM stage (P < 0.001) but not with pathological grade, tumor size, or CEA level (all P > 0.05) (Supplementary Figure 1B-1F). The gene discussed is LYN; the disease is neoplasm.