In the final model, obesity (1.29–3.20), physical activity (1.56–4.75), low HDL-C (3.21–8.30), combination regimen (Thiazide, calcium channel blockers and Angiotensin converting enzyme inhibitors) (1.01–3.17) and being on two (0.09–0.83) or three drugs (0.11–0.95) were the independent and significant determinants of uncontrolled hypertension. The gene discussed is ACE; the disease is obesity due to melanocortin 4 receptor deficiency.