In the final model, obesity (1.29–3.20), physical activity (1.56–4.75), low HDL-C (3.21–8.30), combination regimen (Thiazide, calcium channel blockers and Angiotensin converting enzyme inhibitors) (1.01–3.17) and being on two (0.09–0.83) or three drugs (0.11–0.95) were the independent and significant determinants of uncontrolled hypertension. This evidence concerns the gene ACE and Obesity.