Both plasma and liver concentrations of TNF-α (plasma, p < 0.0001; liver, p = 0.0006), KC/GRO (CXCL1; plasma, p < 0.0001; liver, p = 0.0098) and MCP-1 (CCL2; plasma, p = 0.0014; liver, p < 0.0001) were significantly elevated in GAN DIO-NASH mice compared to chow-fed controls. This evidence concerns the gene CXCL1 and metabolic dysfunction-associated steatohepatitis.