NASH patients (n = 11) demonstrated significant increases in the fractional (%) area of liver fat (8-fold increase; 24.2 ± 2.6 vs. 2.9 ± 0.4%, p < 0.0001), galectin-3 (16-fold increase; 1.6 ± 0.4 vs 0.1 ± 0.02, p = 0.0016) and PSR (2-fold increase; 3.2 ± 0.6 vs. 1.7 ± 0.2, p < 0.0122) as compared to normal-weight healthy individuals (n = 12–14). This evidence concerns the gene LGALS3 and metabolic dysfunction-associated steatohepatitis.