Correspondingly, GAN DIO-NASH mice (n = 25) showed significant increases in % area of liver fat (25-fold increase; 29.8 ± 1.3 vs. 1.2 ± 0.2%, p < 0.0001), galectin-3 (6-fold increase; 5.0 ± 0.3 vs 0.9 ± 0.1%, p < 0.0001) and PSR (5-fold increase; 1.1 ± 0.2 vs. 0.2 ± 0.02%, p = 0.0064) as compared to chow-fed lean mice (n = 10). Here, LGALS3 is linked to metabolic dysfunction-associated steatohepatitis.