To identify more useful prognostic biomarkers for HCC, using bioinformatics based on TCGA, we established 15 gene signatures (including METTL3, METTL14, KIAA1429, RBM15, ZC3H13, WTAP, YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, HNRNPC, HNRNPA2B1, ALKBH5, and FTO) for HCC prognosis prediction. This evidence concerns the gene YTHDC1 and hepatocellular carcinoma.