To identify more useful prognostic biomarkers for HCC, using bioinformatics based on TCGA, we established 15 gene signatures (including METTL3, METTL14, KIAA1429, RBM15, ZC3H13, WTAP, YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, HNRNPC, HNRNPA2B1, ALKBH5, and FTO) for HCC prognosis prediction. The gene discussed is YTHDF3; the disease is hepatocellular carcinoma.