We constructed a gene expression heatmap with 15 m6Amethylation-related genes to get an overview for the expression in HCC, according to TCGA, 11 genes (METTL3, YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, FTO, KIAA1429, HNRNPC, HNRNPA2B1, and RBM15) showed significant upregulation in tumors compared with that in adjacent normal tissue in HCC (Figure 1(a)). The gene discussed is YTHDF3; the disease is hepatocellular carcinoma.