The differential expression of 15 m6A methylation-related genes (METTL3, METTL14, WTAP, YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, FTO, KIAA1429, ALKBH5, FTO, HNRNPC, HNRNPA2B1, and RBM15) in HCC and normal control samples were evaluated using R software (Version 3.8; http://www.bioconductor.org/packages/release/bioc/html). The gene discussed is YTHDF1; the disease is hepatocellular carcinoma.